P450 amount of the main intestinal section of male rat
Results from three male rats in each case are expressed as means ± S.D. (%). The percentage shown in parentheses refers to the relative contribution of the given P450 to the sum of CYP P450 amount in the respective segment.
Duodenum | Upper Jejunum | Middle Jejunum | Lower Jejunum | Ileum | Colon | Liver | |
|---|---|---|---|---|---|---|---|
| fmol mg protein | |||||||
| CYP2B1 | 338 ± 113 (62) | 392 ± 102 (66) | 346 ± 106 (67) | 332 ± 46 (64) | 1718 ± 992 (23) | ||
| CYP3A | 150 ± 20 (28) | 153 ± 52 (26) | 141 ± 35 (27) | 135 ± 41 (26) | 1458 ± 540 (20) | ||
| CYP2D1 | 51 ± 21 (9) | 46 ± 8 (8) | 25 ± 9 (5) | 46 ± 30 (9) | 44 ± 37 (86) | 71 ± 17 (88) | 1897 ± 307 (25) |
| CYP2C6 | 4 ± 1 (1) | 4 ± 1 (<1) | 4 ± 1 (1) | 5 ± 3 (1) | 7 ± 4 (14) | 10 ± 6 (12) | 2373 ± 288 (32) |
| Sum of P450s | 543 ± 155 | 595 ± 163 | 516 ± 151 | 518 ± 120 | 51 ± 41 | 81 ± 23 | 7446 ± 2127 |