TABLE 2

LC 50 values (50% cell death) of arsenic compounds in UROtsa cells and in human hepatocytes after 1-h and 24-h exposure The pentavalent arsenic species MMA(V), DMA(V), and TMAO(V) were not cytotoxic in the tested concentration range up to 5 mM.

LC 50 Values in μM
Asi(III)
Asi(V)
MMA(III)
DMA(III)
UROtsa
1 h 5000 n.ct. 83 15
24 h 170 1530 18 12
Hepatocytes
1 h n.ct. n.ct. 20 13
24 h
130
500
12.4
8.6

  • n.ct., not cytotoxic