Effect of Woohwangcheongsimwon suspension on cytochrome P450 metabolic activity in pooled human liver microsomes with IC50 values
Data are mean ± S.D.
|
| CYP1A2 | CYP2A6 | CYP2B6 | CYP2B6 | CYP2C8 |
| Substrate | Phenacetin | Coumarin | Bupropion | Efavirenz | Rosiglitazone |
| IC50 (%) | >1.5 | >1.5 | 0.18 ± 0.0018 | 0.32 ± 0.034 | >1.5 |
| IC50 (μg/ml)a | >1000 | >1000 | 110 ± 1.1 | 190 ± 20 | >1000 |
|
| CYP2C9 | CYP2C19 | CYP2D6 | CYP2E1 | CYP3A4 |
| Substrate | Tolbutamide | S-Mephenytoin | Dextromethorphan | Chlorzoxazone | Midazolam |
| IC50 (%) | 1.0 ± 0.18 | >1.5 | >1.5 | 1.2 ± 0.087 | >1.5 |
| IC50 (μg/ml)a | 620 ± 110 | >1000 | >1000 | 700 ± 53 | >1000 |
↵ a IC50 values are based on dry weight of Woohwangcheongsimwon suspension.