Pharmacokinetic parameters of β-lactam antibiotics in humans
Mol. Wt. | Dose | CLtotal | Xurine | References | |
|---|---|---|---|---|---|
| mg | ml/min/kg | % dose | |||
| Cefoperazone | 645 | 1000a | 2.14 | 40.0 | Chemotherapy27 (Suppl 6):369-384, 1980 (in Japanese) |
| Cefbuperazone | 627 | 1000a | 1.08 | 92.5 | Chemotherapy30 (Suppl 3):640-661, 1982 (in Japanese) |
| Cefpiramide | 612 | 1000a | 0.26 | 25.2 | Chemotherapy31 (Suppl 1):144-157, 1983 (in Japanese) |
| Cefotetan | 576 | 1000a | 0.41 | 83.0 | Chemotherapy30 (Suppl 1):163-173, 1982 (in Japanese) |
| Ceftriaxone | 554 | 1000a | 0.26 | 54.3 | Chemotherapy32 (Suppl 7):98-125, 1984 (in Japanese) |
| Cefotiam | 525 | 500a | 6.21 | 78.9 | Chemotherapy27 (Suppl 3):192-200, 1979 (in Japanese) |
| Cefmetazole | 471 | 1000a | 1.76 | 83.9 | Chemotherapy26 (Suppl 5):145-154, 1978 (in Japanese) |
| Cefamandole | 462 | 1000a | 3.45 | 96.7 | Chemotherapy27 (Suppl 5):135-144, 1979 (in Japanese) |
| Cefazolin | 454 | 500a | 1.29 | 81.9 | Chemotherapy24:811-823, 1976 (in Japanese) |
| Cefixime | 453 | 100a | 0.98 | 64.8 | Jpn J Clin Pharmacol Ther17:559-568, 1986 (in Japanese) |
| Ceftezole | 440 | 500a | 3.34 | 88.8 | Chemotherapy24:811-823, 1976 (in Japanese) |
| Cefuroxime | 424 | 500a | 1.97 | 83.0 | Biopharm Drug Dispos8:519-526, 1987 |
| Cefdinir | 395 | 200b | N.A. | 23.0 | Antimicrob Agents Chemother39:1082-1086, 1995 |
| Cephalexin | 347 | 250b | N.A. | 88.7 | Biopharm Drug Dispos17:319-330, 1996 |