IQ metabolites in rat and mouse urine
Urine samples from rats and mice were analyzed by HPLC as illustrated in Fig. 2. The relative abundance of excreted metabolites is provide by table entries as the mean ± S.E. of four rats and four mice. Rodents were administered [14C]IQ and placed in metabolic cages for a 24-h urine collection.
Condition | N-Glucuronide | 5-O-Glucuronide | Sulfamate | 5-Sulfate | Demethyl-IQ | ||||
|---|---|---|---|---|---|---|---|---|---|
| % of total urine radioactivity | |||||||||
| Rat | 5.0 ± 0.6 | 35 ± 1 | 30 ± 2* | 15 ± 0.9* | 0.9 ± 0.2* | ||||
| Mouse | 5.2 ± 0.4 | 36 ± 1 | 11 ± 1 | 3.8 ± 0.1 | 26 ± 2 | ||||
↵* Significantly different from mouse (P < 0.05).