Concentration of radioactivity in blood and tissues at specified times postdose determined by whole-body autoradiography for female mice following i.v. administration of [14C]DPC 333
Results are in nanocuries per gram tissue.
Animal Sacrifice Time | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tissuea | 2 min | 5 min | 15 min | 30 min | 1 h | 2 h | 4 h | 6 h | 12 h | 24 h | |||||||||
| Blood | 864.6 | 654.2 | 204.6 | 118.6 | 37.30 | 28.10 | 19.70 | 23.20 | 14.60 | 11.40 | |||||||||
| Bone marrow | 529.4 | 457.5 | 161.6 | 63.40 | 20.20 | 14.90 | 8.300 | 10.40 | 6.000 | 3.200 | |||||||||
| Brain | 14.40 | 10.80 | 4.000 | 2.300 | 0.9000 | 0.7000 | 0.5000 | 0.6000 | 0.4000 | 0.3000 | |||||||||
| Brown fat | 497.1 | 485.6 | 170.3 | 90.70 | 36.80 | 20.00 | 12.00 | 14.80 | 5.700 | 3.600 | |||||||||
| Gall bladder contents | N.R. | 25,420 | 15,340 | 37,810 | 32,590 | 44,500 | 17,350 | N.R. | N.R. | N.R. | |||||||||
| Heart | 1061 | 559.3 | 121.0 | 54.10 | 15.10 | 12.90 | 7.700 | 11.00 | 5.500 | 3.800 | |||||||||
| Kidney | 1732 | 1915 | 692.0 | 324.3 | 56.80 | 42.30 | 31.80 | 37.80 | 14.00 | 7.400 | |||||||||
| Lacrimal gland | 1023 | 620.0 | 187.4 | N.R. | 27.30 | 16.80 | N.R. | 10.20 | 4.800 | 2.200 | |||||||||
| Liver | 3135 | 2793 | 1049 | 597.6 | 170.1 | 106.6 | 98.20 | 95.20 | 36.50 | 17.60 | |||||||||
| Lymph nodes | 144.4 | 298.8 | 175.2 | 112.8 | 67.90 | 46.00 | 13.40 | 8.000 | 10.50 | 4.800 | |||||||||
| Lung | 853.7 | 347.7 | 196.4 | 92.70 | 26.30 | 22.70 | 17.60 | 19.20 | 16.70 | 7.500 | |||||||||
| Salivary gland | 1287 | 805.8 | 260.0 | 106.9 | 24.90 | 21.50 | 16.50 | 15.90 | 6.500 | 3.300 | |||||||||
| Skeletal muscle | 229.3 | 171.3 | 80.70 | 28.20 | 5.500 | 2.90 | 2.100 | 2.400 | 1.500 | 0.9000 | |||||||||
| Skin | 136.0 | 169.4 | 92.80 | 59.00 | 19.30 | 11.30 | 5.400 | 8.100 | 4.800 | 3.900 | |||||||||
| Spleen | 343.0 | 433.3 | 266.4 | 128.4 | N.R. | 42.60 | 21.60 | 17.90 | 7.600 | 4.400 | |||||||||
| White fat | 147.0 | 103.5 | 69.40 | 43.10 | 19.70 | 11.20 | 6.200 | 3.400 | 1.900 | 1.800 | |||||||||
N.R., not represented (tissue or organ not present in original section).
LLOQ = 1.263 nCi/g.
↵ a Intestinal contents exceeded upper linear range and therefore were not quantitated.