Pharmacokinetic Parameters | Units | CYP2C9*1/*1 (n = 11) | CYP2C9*1/*3 (n = 8) | CYP2C9*3/*3 (n = 2) |
---|---|---|---|---|
200 mg of fluconazole | ||||
AUC0–24 | Micrograms · milliliter–1 · hour | 265 (187–395) | 248 (142–293) | 158, 262 |
T1/2 | Hours | 31.6 (13.3–46.4) | 27.3 (14.7–46.7) | 34.6, 51.6 |
Cmax | Micrograms · milliliter–1 | 14.5 (11.3–19.6) | 14.4 (9.2–16.0) | 9.6, 20.3 |
400 mg of fluconazole | ||||
AUC0–24 | Micrograms · milliliter–1 · hour | 543 (362–742) | 515 (474–722) | 330, 490 |
T1/2 | Hours | 35.4 (17.9–54.9) | 42.0 (15.5, 55.2) | (49.5, 51.1) |
Cmax | Micrograms · milliliter–1 | 27.8 (19.6–42.1) | 26.4 (23.3–47.0) | 18.8, 24.6 |