TABLE 4

Noncompartmental pharmacokinetic parameters of fluconazole after 200 mg or 400 mg coadministration for 7 days Data are shown as median (range), except for CYP2C9*3/*3 genotype group, in which individual data are presented.


Pharmacokinetic Parameters

Units

CYP2C9*1/*1 (n = 11)

CYP2C9*1/*3 (n = 8)

CYP2C9*3/*3 (n = 2)
200 mg of fluconazole
   AUC0–24 Micrograms · milliliter–1 · hour 265 (187–395) 248 (142–293) 158, 262
   T1/2 Hours 31.6 (13.3–46.4) 27.3 (14.7–46.7) 34.6, 51.6
   Cmax Micrograms · milliliter–1 14.5 (11.3–19.6) 14.4 (9.2–16.0) 9.6, 20.3
400 mg of fluconazole
   AUC0–24 Micrograms · milliliter–1 · hour 543 (362–742) 515 (474–722) 330, 490
   T1/2 Hours 35.4 (17.9–54.9) 42.0 (15.5, 55.2) (49.5, 51.1)
   Cmax
Micrograms · milliliter–1
27.8 (19.6–42.1)
26.4 (23.3–47.0)
18.8, 24.6