TABLE 2

Transcellular transport of the test compounds across the monolayers of polarized cell lines expressing mouse Bcrp or Mdr1a and their corresponding control cells

Data were taken from Figs. 4 and 6. Permeabilities were obtained from the slopes of the transcellular transport from 40 to 120 min and the concentration in the donor compartment.

Compound	Cell Line	Permeability
Compound	Cell Line			Apical-to-Basal	Basal-to-Apical
		μl/min/well
MeIQx	MDCK II/GFP	0.371 ± 0.038	0.387 ± 0.042
	MDCK II/Bcrp	0.180 ± 0.014**	0.754 ± 0.005**
	LLC-PK1	0.577 ± 0.04	0.733 ± 0.007
	L-Mdr1a	0.389 ± 0.02*	0.867 ± 0.018**
PhIP	MDCK II/GFP	0.771 ± 0.047	0.947 ± 0.032
	MDCK II/Bcrp	0.410 ± 0.030**	1.61 ± 0.06**
	LLC-PK1	0.832 ± 0.056	1.65 ± 0.04
	L-Mdr1a	0.452 ± 0.025**	2.39 ± 0.06**
Dantrolene	MDCK II/GFP	0.643 ± 0.071	0.723 ± 0.019
	MDCK II/Bcrp	0.394 ± 0.028*	1.11 ± 0.05**
	LLC-PK1	0.719 ± 0.047	1.32 ± 0.01
	L-Mdr1a	0.732 ± 0.026	1.43 ± 0.05
Prazosin	MDCK II/GFP	0.546 ± 0.019	0.971 ± 0.029
	MDCK II/Bcrp	0.339 ± 0.038**	1.56 ± 0.06**
	LLC-PK1	0.678 ± 0.063	0.996 ± 0.049
	L-Mdr1a	0.270 ± 0.026**	2.59 ± 0.17**
Triamterene	MDCK II/GFP	0.397 ± 0.016	0.358 ± 0.009
	MDCK II/Bcrp	0.207 ± 0.008**	0.730 ± 0.045**
	LLC-PK1	0.384 ± 0.038	0.781 ± 0.004
	L-Mdr1a	0.196 ± 0.007**	0.860 ± 0.039

Asterisks represent statistically significant differences in the permeability between transporter-expressing cells and the corresponding control cells; *, P < 0.05; and **, P < 0.01.