Total Fluconazole in Incubation | Fluconazole Extracellular | fA | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
CYP1A2 | CYP2C9 | CYP2C19 | CYP2D6 | CYP3A4 | ||||||
μM | % | |||||||||
100 μM | 98.4 | 91.9 | 21.2 | 10.6 | 74.2 | 15.4 | ||||
50 μM | 47.2 | 112 | 36.8 | 14.9 | 97.6 | 23.3 | ||||
25 μM | 26.5 | 89.5 | 55.2 | 27.8 | 102 | 34.9 | ||||
12.5 μM | 13.1 | 97.5 | 66.3 | 45.2 | 87.4 | 39.8 | ||||
6.25 μM | 6.10 | 90.8 | 78.9 | 64.7 | 115 | 50.6 | ||||
3.13 μM | 3.13 | 85.1 | 86.7 | 75.7 | 110 | 59.9 | ||||
1.56 μM | 1.46 | 90.0 | 89.3 | 89.2 | 89.0 | 66.7 | ||||
0 μM | 0 | 100 | 100 | 100 | 100 | 100 |