Relative P450 contribution to the hepatic metabolism, fluconazole dose, and estimated Cmax
Compound | fm | Fluconazole Dosea | Cmax b | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CYP1A2 | CYP2C9 | CYP2C19 | CYP2D6 | CYP3A4/5 | |||||||
| μM | |||||||||||
| Theophylline | 1 | NA | NA | NA | NA | 200 mg b.i.d. | 34.6 | ||||
| Tolbutamide | NA | 0.72 | 0.28 | NA | NA | 200 mg q.d. | 34.6 | ||||
| Omeprazole | NA | NA | 0.60 | NA | 0.40 | 100 mg q.d. | 17.3 | ||||
| S-Warfarin | NA | 1 | NA | NA | NA | 300 mg q.d. | 51.9 | ||||
| Phenytoin | NA | 0.90 | 0.10 | NA | NA | 200 mg q.d. | 34.6 | ||||
| Midazolam | NA | NA | NA | NA | 0.94 | 200 mg q.d. | 34.6 | ||||
| Sirolimus | 0 | 0.15 | 0 | 0 | 0.85 | 200 mg q.d. | 34.6 | ||||
| Cyclosporine | NA | NA | NA | NA | 0.71 | 200 mg q.d. | 34.6 | ||||
| Tacrolimus | 0 | 0.08 | 0 | 0.01 | 0.47 | 200 mg q.d. | 34.6 | ||||