TABLE 3
Area under plasma concentration-time curve from 1 to 24 h (AUC1–24 h) of GL and its metabolites when GL was orally administered to rats fed the CSAA or CDAA diet Wistar rats were fed CSAA or CDAA diet for 4 or 12 weeks. GL (100 mg/kg) was orally administered to the rat, and the blood samples were collected 1, 2, 4, 8, 12, and 24 h after the treatment. Plasma concentrations of GL and its metabolites, 3MGA and GA, were measured as described under Materials and Methods. AUC1–24 h was calculated from the plasma measurements using the trapezoidal rule from the first point to the last point.