In Vivo Abbreviations
Abbreviation | Definition | Measured | Predicted | Equation Number |
|---|---|---|---|---|
| X | Amount | √ | Supplemental data | |
| C | Concentration | √ | √ | Supplemental data |
| V | Volume | √ | 18 | |
| B | Blood compartment | √ | √ | 16 |
| LV | Liver vascular compartment | √ | 18 | |
| L,cell | Liver cellular compartment | √ | 18 | |
| L,mem | Liver cell membrane compartment | √ | 18 | |
| LI | Liver interstitial compartment | √ | 18 | |
| I | Interstitial compartment | √ | 18 | |
| T | Tissue compartment | √ | 18 | |
| CLint,L,uptake | Liver unbound sinusoidal uptake intrinsic clearance | √ | 16, 17 | |
| CLint,L,efflux | Liver unbound sinusoidal efflux intrinsic clearance | √ | 16, 17 | |
| CLint,L,pass | Liver unbound passive diffusion intrinsic clearance | √ | 16, 17 | |
| CLint,L | Liver unbound intrinsic clearance | √ | 16, 17 | |
| fuB | Unbound fraction in blood | √ | 16, 18 | |
| fuLI | Unbound fraction in liver interstitial | √ | 18 | |
| fuI | Unbound fraction in interstitial | √ | 18 | |
| fuL,cell | Unbound fraction in liver cellular | √ | 18 | |
| k L,mem | Proportionality constant between amount in liver cell membrane and free concentration of liver vascular compartment | √ | 18 | |
| fuT (fuL) | Unbound fraction in body tissue (from liver homogenate) | √ | 18 | |
| CLB | Clearance from blood | √ | √ | 18 |
| MRT | Mean residence time | √ | √ | Supplemental data |
| Vss | Steady-state volume of distribution | √ | √ | 18 |
|
t
1/2
| Blood β phase half-life | √ | √ | Simulated |