Observed in vitro parameters for atorvastatin, cerivastatin, and indomethacin in rat hepatocytes and tissue Data are mean ± S.D., and n = 3 unless otherwise stated.
Atorvastatin | Cerivastatin | Indomethacin | |
|---|---|---|---|
| fuinc | 0.71, 0.67 | 0.61, 0.61 | 0.78 ± 0.23 |
| fup | 0.04, 0.024 | 0.026, 0.032 | 0.002 ± 0.001 |
| Blood/plasma ratio | 1.3 ± 0.2 | 0.7, 0.7 | 0.7 ± 0.1 |
| fuL | 0.03, 0.03 | 0.021, 0.015 | 0.07, 0.08 |
| CLinc (μl/min/106 cells) | 15 ± 5.6 | 6.0 ± 3.0 | 6.7 ± 1.9 |
| CLmed (μl/min/106 cells) | 85 ± 28 | 26 ± 19 | 13 ± 6.7 |
| Vssmed (ml/106 cells)* | 4.7 ± 1.1 | 5.5 ± 1.2 | 1.9 ± 0.4 |
| fmed,60 | 0.1 ± 0 | 0.14 ± 0.05 | 0.45 ± 0.14 |
↵* At a cell concentration of 1 × 106 cells/ml