Derived and associated predicted in vitro parameters for atorvastatin, cerivastatin, and indomethacin Data are mean ± S.D., and n = 3 unless otherwise stated.
Atorvastatin | Cerivastatin | Indomethacin | |
|---|---|---|---|
| CLint,uptake (μl/min/106 cells) | 375 ± 45 | 413 ± 47 | 599 ± 101 |
| CLint,pass (μl/min/106 cells) | 17 ± 4.5 | 58 ± 12 | 237 ± 63 |
| CLint,met (μl/min/106 cells) | 4.3 ± 0.65 | 2.3 ± 0.6 | 1.0 ± 0.49 |
| Ψ | 18 | 7.8 | 3.5 |
| kmem (ml) | 0.092 ± 0.007 | 0.15 ± 0.04 | 0.15 ± 0.13 |
| fucell | 0.011 ± 0.0002 | 0.0081 ± 0.001 | 0.054 ± 0.041 |
| CLinc (μl/min/106 cells) | 10 ± 7 | 3.0 ± 2.8 | 4.0 ± 2.3 |
| CLmed (μl/min/106 cells) | 68 ± 31 | 17 ± 14 | 7 ± 4 |
| Vssmed (ml/106 cells)* | 8 ± 2 | 5 ± 1.6 | 2 ± 0.4 |
| fmed,ss | 0.14 ± 0.04 | 0.2 ± 0.06 | 0.54 ± 0.1 |
↵* At a cell concentration of 1 × 106 cells/ml