Atorvastatin | Cerivastatin | Indomethacin | |
---|---|---|---|
Standard scaling | |||
Metabolic CL (ml/min/kg) | 12 | 5 | 0.9 |
Seven-compartment model | |||
Metabolic CL (ml/min/kg) | 24 | 8.4 | 0.18 |
Vss (l/kg) | 1.4 | 1.3 | 0.14 |
Plasma Css (ng/ml) | 670 | 1600 | 4400 |
Liver Css (ng/g tissue) | 10,000 | 24,000 | 1400 |
Liver/plasma ratio | 15 | 15 | 0.31 |
Liver cell Css (ng/g tissue) | 16,000 | 38,000 | 680 |
Liver free cell/plasma free ratio | 8.3 | 7.2 | 4.2 |
Muscle Css (ng/g tissue) | 670 | 780 | 140 |
Muscle/plasma ratio | 1.0 | 0.5 | 0.03 |
Half-life (h) | 0.82 | 3.4 | 8.2 |