Variable | Placebo Phase | UDCA Phase |
---|---|---|
Cmax (ng/ml) | 17.2 ± 8.91 | 22.8 ± 15.3 |
Tmax (h) | 2 (0.5–5) | 2 (1–3) |
t1/2 (h) | 31.6 ± 10.5 | 50.3 ± 51.4 |
AUC0–72 (ng/ml · h) | 128.5 ± 47.1 | 182.1 ± 73.3** |
AUC0-∞ (ng/ml · h) | 145.8 ± 58.5 | 232.0 ± 104.8** |
TB (μM) | 9.27 ± 2.13 | 12.5 ± 2.66** |
CB (μM) | 4.41 ± 0.84 | 5.47 ± 0.82** |
UB (μM) | 4.86 ± 1.32 | 7.03 ± 1.90** |
Cmax, peak plasma concentration; Tmax, time to peak plasma concentration; t1/2, elimination half-life; AUC0–72, area under plasma concentration-time curve from time 0 to 72 h; AUC0-∞, area under plasma concentration-time curve from time 0 to infinity
↵** P < 0.01