Hepatocyte/medium concentration ratios for total (Kp) and unbound (Kpu) and intracellular fraction unbound for saquinavir, nelfinavir, and ritonavir Mean of duplicate determinations.
Kp | Kpu | Intracellular fraction unbound | |
|---|---|---|---|
| Saquinavir | 306 | 6.8 | 0.022 |
| Ritonavir | 616 | 11.4 | 0.018 |
| Nelfinavir | 3352 | 5.7 | 0.0017 |