TABLE 5

Comparison of predicted metabolic clearance and permeability parameters from hepatic microsomes and hepatocytes, expressed per unit weight of liver and hepatic extraction ratios reported in vivo and predicted from the vitro systems

	Microsomal Clearance^a	Predicted Extraction Ratio from Microsomes^b	Hepatocytes Permeability^a	Predicted Extraction Ratio from Hepatocytes^b	Hepatocytes Clearance^a
	ml/min/g liver		ml/min/g liver		ml/min/g liver
Saquinavir	650	0.95	57	0.67	53
Ritonavir	714	0.96	117	0.81	80
Nelfinavir	940	0.96	284	0.87	141

↵ a Scaled to whole liver with scaling factors listed under Materials and Methods
↵ b Calculated from the well-stirred liver model with fu in blood from Shibata et al. (2002a) and a hepatic blood flow of 100 ml/min/kg