Fitted model parameters for phenyl glucuronide from the aqueous phenol exposure study Parameter S.E. values are given in parentheses. Summary data are given as the mean ± S.E.
Fish | k12 | k20 | VD,PG | CLPGa | k12/k10d | |
|---|---|---|---|---|---|---|
| 1/h | l/kg | ml/h/kg | ||||
| 5 | 0.024 (0.001) | 0.024 (0.003) | 0.36b | 8.5 | 0.05 | |
| 6 | 0.037 (0.003) | 0.051 (0.007) | 0.36b | 18.5 | 0.06 | |
| 7 | 0.048 (0.005) | 0.038 (0.006) | 0.41 (0.07) | 15.7 | 0.06 | |
| 8 | 0.066 (0.004) | 0.026 (0.002) | 0.40 (0.03) | 10.4 | 0.08 | |
| 9 | 0.059 (0.004) | 0.066 (0.007) | 0.36b | 23.6 | 0.10 | |
| 10 | 0.061 (0.003) | 0.040 (0.003) | 0.27 (0.02) | 11.1 | 0.09 | |
|
| 0.049 ± 0.006 | 0.041 ± 0.006 | 0.36 ± 0.02c | 14.6 ± 2.1 | 0.07 ± 0.01 | |
↵ a Calculated as the product k20VD,PG × 1000
↵ b Set equal to the mean of values determined for fish 7, 8, and 10
↵ c Calculated using data from fish 7, 8, and 10
↵ d The value of k10 was determined by fitting model simulations to measured phenol concentrations in blood (see Table 3). This rate constant represents all processes responsible for the elimination of phenol