Pharmacokinetic Parameters | Wild-Type FVB Mouse | Bcrp1–/– FVB Mouse | ||||
---|---|---|---|---|---|---|
Plasma | Brain | Plasma | Brain | |||
λz (min–1) | 0.05 | 0.04 | 0.07 | 0.05 | ||
Half-life (min) | 13 | 17 | 10 | 14 | ||
Clearance (ml/min/kg) | 48 | 50 | ||||
Volume of distribution (l/kg) | 0.9 | 0.7 | ||||
AUC(0–∞) (μg · min/ml)a | 311 ± 13 | 18.2 ± 0.8 | 298 ± 12 | 17.6 ± 1.3 | ||
AUCbrain/AUCplasma | 0.06 | 0.06 | ||||
Drug targeting index |
| 1 |
|
↵ a Mean ± S.D.