Pharmacokinetic Parameters | Wild-Type FVB Mouse | Bcrp–/– FVB Mouse | ||||
---|---|---|---|---|---|---|
Plasma | Brain | Plasma | Brain | |||
λz (min–1) | 0.05 | 0.05 | 0.04 | 0.03 | ||
Half-life (min) | 14 | 15 | 20 | 21 | ||
Clearance (ml/min/kg) | 39 | 50 | ||||
Volume of distribution (l/kg) | 0.8 | 1.43 | ||||
AUC(0–∞) (μg · min/ml)a | 256 ± 17.5 | 26.3 ± 2.3 | 202 ± 10.2* | 31.6 ± 1.5 | ||
AUCbrain/AUCplasma | 0.10 | 0.15 | ||||
Drug targeting index |
| 1.5 |
|