TABLE 2

The proximal-to-distal patterns for pgp = 419 and cyp = 480

ISID Segment
1 Proximal
2
3
4
5
6
7
8 Distal
Length (% total) 0–12.5 12.5–25 25–37.5 37.5–50 50–62.5 62.5–75 75–87.5 87.5–100
In vivo cyp relative levela 0.63 0.83 1.00 0.71 0.79 0.83 0.75 0.62
In silico cyp objects 49 65 78 55 62 65 58 48
In vivo pgp relative levelb 0.64 0.77 0.87 0.85 0.92 1.00 0.98 0.97
In silico pgp objects 38 46 52 51 55 60 59 58
cyp/pgp ratio
1.3
1.8
1.5
1.1
1.1
1.1
1.0
0.8

  • ↵ a Relative ratios taken from Paine et al. (1997)

  • ↵ b Relative ratios taken from Mouly et al. (2003)