Time | 80 Min | 200 Min | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cyp/pgp exists? | cyp = 0 | cyp = 1 | cyp = 0 | cyp = 1 | cyp = 0 | cyp = 1 | cyp = 0 | cyp = 1 | ||||||||
Yes, 1; No, 0 | pgp = 0 | pgp = 0 | pgp = 1 | pgp = 1 | pgp = 0 | pgp = 0 | pgp = 1 | pgp = 1 | ||||||||
Nonspecific binding absent | Observed SD | 9.22 | 16.85 | 13.08 | 11.88 | 10.96 | 19.10 | 14.87 | 12.97 | |||||||
Observed mean | 262.1 | 239.4 | 136.4 | 121.2a | 387.5 | 351.5 | 209.4 | 186.9b | ||||||||
Expected mean | 113.7 | 173.4* | ||||||||||||||
With nonspecific binding | Observed SD | 15.49 | 13.28 | 12.91 | 9.57 | 13.00 | 15.52 | 15.55 | 11.26 | |||||||
Observed mean | 244.2 | 204.0 | 122.3 | 101.0c | 367.8 | 307.0 | 185.9 | 152.5d | ||||||||
| Expected mean |
|
|
| 82.1** |
|
|
| 125.0** |
↵* Significantly less than the corresponding, observed mean with p < 0.05
↵** Significantly less than the corresponding, observed mean with p < 0.001
↵ a 95% Confidence interval: (116.6, 125.7)
↵ b 95% Confidence interval: (181.8, 191.9)
↵ c 95% Confidence interval: (97.3, 104.7)
↵ d 95% Confidence interval: (148.1, 156.9)