Kinetic parameters for the OAT1-, OAT2-, and OAT3-mediated uptake of [14C]zonampanel in rats and humans
Rat | Human Kma | |||||||
|---|---|---|---|---|---|---|---|---|
| Km
b
| Vmax
b
| Pdif
b
| Vmax/Km | |||||
| μM | pmol/min/mg protein | μl/min/mg protein | μM | |||||
| OAT1 | 13.4 ± 1.6 | 454 ± 46 | 1.12 ± 0.44 | 33.9 | 1.4 | |||
| OAT2 | 13.4 ± 1.9 | 118 ± 14 | 0.508 ± 0.098 | 8.81 | N.T. | |||
| OAT3 | 53.6 ± 9.8 | 226 ± 36 | 0.467 ± 0.043 | 4.22 | 7.7 | |||
N.T., not transported
↵ a Cited from our previous study (Hashimoto et al., 2004)
↵ b Parameters were calculated from the data in Fig. 3 (estimate ± S.E.)