Substrate | Canine P450 Isoform Implicated | ||||||||
---|---|---|---|---|---|---|---|---|---|
CYP1A1/2 | CYP2B11 | CYP2C21/41 | CYP2D15 | CYP3A12/26 | |||||
Phenacetin (50 μM)a | Substrate | 5 | –7 | –5 | 0 | ||||
Temazepam (80 μM) | –13 | Substrate | –35 | 0 | 25 | ||||
Diclofenac (30 μM) | 5 | –5 | Substrate | –7 | –5 | ||||
Bufuralol (5 μM) | 5 | 0 | 0 | Substrate | –15 | ||||
Midazolam (2 μM) | 10 | –14 | –7 | –20 | Substrate | ||||
Cocktail | –13 | –23 | –28 | –24 | –2 | ||||
Cocktail without temazepam | –6 | NA | –6 | –27 | –3 |