Treatment | Number of Animals | Study Drugs | Route of Administration | Doses | Sampling Site | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Plasma (VP, VH, VF) | Bile | Intestinal Perfusion | Liver Samples | ||||||||
mg | min | ||||||||||
Part I: TI | 6 | Ximelagatran | Jejunum | 200 | Yes | Yes | 0–100 | Yes | |||
Part I: TII | 6 | Ximelagatran + erythromycin | Jejunum | 200 + 250 | Yes | Yes | 0–100 | Yes | |||
Part II: TIII | 4 | Ximelagatran | i.v. | 15 | Yes | Yes | 0–360 | No | |||
Part II: TIV | 4 | Melagatran | i.v. | 15 | Yes | Yes | 0–360 | No |