Plasma PK of TSL in dogs after a p.o. dose of cardiotonic pills or an i.v. bolus dose of the injectable TSL solution For AUC0→t, the value of t is defined as the last quantifiable point; these were 2, 2, 4, or 4 h after the low, intermediate, high p.o. dose of cardiotonic pills, or the i.v. dose of the injectable TSL solution, respectively.
PK Parameter | Dose of TSL from p.o. Cardiotonic Pills [pills/kg] | i.v. TSL Dose 0.64 | ||||
|---|---|---|---|---|---|---|
| 0.32 [2] | 0.64 [4] | 1.28 [8] | ||||
| mg/kg | mg/kg | mg/kg | mg/kg | |||
| Cmax (ng/ml) | 329 ± 122 | 774 ± 50 | 1034 ± 219 | 2791 ± 500 | ||
| Tpeak (h) | 0.44 ± 0.10 | 0.33 ± 0.00 | 0.50 ± 0.00 | |||
| AUC0→t (h · ng/ml) | 211 ± 18.7 | 447 ± 22.7 | 909 ± 158 | 1143 ± 82.6 | ||
| AUC0→∞ (h · ng/ml) | 223 ± 17.1 | 454 ± 19.8 | 911 ± 157 | 1145 ± 82.8 | ||
| MRT (h) | 0.90 ± 0.16 | 0.73 ± 0.04 | 0.99 ± 0.12 | 0.46 ± 0.03 | ||
| t1/2 (h) | 0.40 ± 0.05 | 0.44 ± 0.04 | 0.55 ± 0.07 | 0.44 ± 0.03 | ||
| CLtot,p (l/h · kg) | 0.51 ± 0.04 | |||||
| Vss (l/kg) | 0.24 ± 0.03 | |||||
| F (%) |
| 39.7 ± 1.2 |
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