Pharmacokinetic parameters for ceramide, ceramide liposome, and control liposomes Pharmacokinetic parameters were determined by noncompartmental analysis of plasma time profiles. Data are means ± S.D. from n = 4 to 5 rats.
Co | AUC | CL Calculated | t1/2 | Vd | |
|---|---|---|---|---|---|
| μg/ml | μg · h/ml | ml/kg | h | ml/kg | |
| Ceramide | 7.96 ± 3.20 | 42.62 ± 3.60 | 165.19 ± 13.80 | 17.19 ± 1.09 | 1020 ± 478 |
| Ceramide liposome | 868.40 ± 325.62 | 14,017 ± 1449 | 3.60 ± 0.39 | 14.37 ± 2.21 | 63 ± 19 |
| Control liposome | 787.27 ± 170.29 | 12,802 ± 2912 | 4.08 ± 0.95 | 14.79 ± 2.19 | 66 ± 13 |