Kinetic parameters of UGT activities in duodenal microsomes from male mice and rats
TFP N-glucuronide was not detected in microsomes from male mice and rats.
Substrate | Species | Km (S50) | Vmax | CLint (CLmax) | n a |
|---|---|---|---|---|---|
| μM | nmol/min/mg protein | μl/min/mg protein | |||
| Estradiol | Mouse | 42 ± 7b | 2.2 ± 0.2 | 28c | 1.6 |
| Rat | 35 ± 10 | 1.3 ± 0.1 | 38 | ||
| 4-MU | Mouse | 164 ± 46 | 63 ± 7 | 387 | |
| Rat | 416 ± 19 | 190 ± 4 | 458 | ||
| 4-NP | Mouse | >1500 | |||
| Rat | 494 ± 117 | 33 ± 4 | 67 | ||
| MPA | Mouse | 1272 ± 349 | 8.9 ± 1.6 | 7.0 | |
| Rat | 340 ± 47 | 6.7 ± 0.4 | 20 | ||
| Morphine | Mouse | 2380 ± 103 | 0.05 ± 0.00 | 0.02 | |
|
| Rat | 320 ± 23 | 0.11 ± 0.00 | 0.34 |
|