Analyte | Species | t1/2 | Cmax | AUC(0-t) | AUC(0-∞) |
---|---|---|---|---|---|
h | ng/ml | ng/h/ml | ng/h/ml | ||
LAS | Male rat | 7.09 | 22.2 | 160 | 172 |
Female rat | 9.43 | 64.0 | 276 | 334 | |
Mean | 8.26 | 43.1 | 218 | 253 | |
Male monkey | 22.0 | 79.2 | 1569 | 2035 | |
Female monkey | 10.8 | 46.4 | 2048 | 2159 | |
Mean | 16.4 | 62.8 | 1809 | 2097 | |
Radioactivity* | Male rat | 11.7 | 90.3 | 820 | 1035 |
Female rat | 14.7 | 90.9 | 1045 | 1525 | |
Mean | 13.2 | 90.6 | 932 | 1280 | |
Male monkey | 27.3 | 318 | 9632 | 13832 | |
Female monkey | 22.2 | 458 | 10813 | 13887 | |
| Mean | 24.8 | 388 | 10222 | 13859 |
↵* Cmax and AUC values for total radioactivity are expressed as nanogram equivalents per milliliter and nanogram equivalents per hour per milliliter, respectively.