TABLE 1

Plasma and liver concentrations (mean ± S.D., n = 3 mice/strain/time point) and liver-to-plasma concentration ratio (K_p,liver) following an s.c. administration of the model compounds at 3 mg/kg to 4- to 6-week-old male Oatp1b2 KO and WT mice

Compound	Time	KO Concentration			KO	WT Concentration			WT
Compound	Time			Plasma	Liver	K_{p, liver}	Plasma	Liver	K_p,liver
	h	ng/ml	ng/ml		ng/ml	ng/ml
Rifampicin	0.5	840 ± 51	13000 ± 1800	2.5 ± 0.3*	3200 ± 872	30000 ± 4300	9.4 ± 1.3
	2	6700 ± 2000	16000 ± 400	2.6 ± 0.6*	3600 ± 470	37000 ± 2300	11 ± 2
Rifamycin SV	0.5	2100 ± 480	20000 ± 2500	9.2 ± 0.7	670 ± 180	14000 ± 3600	23 ± 12
	2	750 ± 21	9200 ± 4400	12 ± 6	120 ± 67	5200 ± 2700	54 ± 35
Cerivastatin	0.5	1100 ± 210	620 ± 84	0.80 ± 0.45	840 ± 250	900 ± 300	1.2 ± 0.6
	2	293 ± 77	120 ± 38	0.25 ± 0.14*	300 ± 42	140 ± 79	0.47 ± 0.30
Lovastatin acid	0.5	380 ± 6	5700 ± 440	16 ± 1*	260 ± 47	6300 ± 930	25 ± 4
	2	50 ± 2	1200 ± 64	22 ± 3*	35 ± 7	1200 ± 390	36 ± 6
Pravastatin	0.5	690 ± 160	2100 ± 820	3.0 ± 1.4	580 ± 71	1300 ± 530	2.3 ± 0.8
	2	120 ± 11	500 ± 97	4.3 ± 0.5	340 ± 190	380 ± 53	1.7 ± 1.4
Simvastatin acid	0.5	580 ± 45	1700 ± 290	3.1 ± 0.6	650 ± 170	2600 ± 1100	4.3 ± 2.2
	2	150 ± 25	600 ± 110	4.2 ± 1.2	16 ± 49	970 ± 180	5.9 ± 0.59

↵* Student's t test shows P < 0.05.