Drug | Covalent Binding (Mean ± S.D.) | ||||
---|---|---|---|---|---|
Complete | (-) NADP | NADPH-Dependent | |||
pmol/mg protein | |||||
Aminopyrine* | 30.9 ± 3.3 | 5.3 ± 3.1 | 25.7 | ||
Amodiaquine* | 208.1 ± 13.4 | 258.2 ± 14.7 | -50.0 | ||
Benzbromarone* | 389.9 ± 18.9 | 4.8 ± 0.5 | 385.1 | ||
Clozapine* | 44.7 ± 2.6 | 19.4 ± 5.7 | 25.3 | ||
Erythromycin | 57.1 ± 6.7 | 4.5 ± 0.2 | 52.6 | ||
Flutamide* | 178.0 ± 10.9 | 12.2 ± 0.3 | 165.8 | ||
Imipramine | 133.8 ± 7.0 | 91.0 ± 15.7 | 42.8 | ||
Nevirapine* | 19.1 ± 1.3 | 20.2 ± 2.0 | -1.2 | ||
Phenacetin | 23.6 ± 3.6 | 14.1 ± 3.0 | 9.4 | ||
Phenytoin | 4.4 ± 0.4 | 2.6 ± 0.3 | 1.7 | ||
Procainamide | 5.1 ± 0.5 | 5.9 ± 0.4 | -0.8 | ||
Sulfamethoxazole | 3.2 ± 0.7 | 2.8 ± 2.0 | 0.5 | ||
Tacrine | 137.0 ± 7.5 | 2.7 ± 0.3 | 134.3 | ||
Valproic acid* | 6.3 ± 3.3 | 2.3 ± 0.2 | 4.0 | ||
Zafirlukast | 36.4 ± 2.0 | 1.7 ± 0.1 | 34.7 | ||
Zomepirac* | 6.4 ± 0.5 | 2.9 ± 0.9 | 3.4 | ||
Amlodipine | 9.1 ± 0.3 | 2.6 ± 0.3 | 6.5 | ||
Caffeine | 9.9 ± 1.6 | 2.3 ± 1.2 | 7.6 | ||
Valsartan | 1.4 ± 0.6 | 0.6 ± 0.2 | 0.7 | ||
Warfarin | 15.9 ± 2.6 | 7.0 ± 3.4 | 8.9 |
↵* “Withdrawn” or “black box warning” drugs.