TABLE 4

Comparison of volume of distribution and clearance estimates from compartmental pharmacokinetic models

Values are means ± S.E.

Animal
Single or Central Compartment
Tissue Compartment
S1CPT
S2CPT
P1M
P2M
P2MNFC
S2CPT
P2M
P2MNFC
Volume (ml)
    Maternal
        267 3100 ± 330 1610 ± 500 2980 ± 240 1600 ± 450 1600 ± 440 1810 ± 450 1660 ± 390 1660 ± 380
        273 2660 ± 430 920 ± 400 2500 ± 260 900 ± 300 893 ± 290 1970 ± 370 1810 ± 270 1810 ± 260
        275 3030 ± 410 1220 ± 270 2950 ± 460 1220 ± 780 1210 ± 760 2280 ± 270 2180 ± 790 2190 ± 760
    Fetal
        267 267 ± 13 266 ± 690 265 ± 18 265 ± 13 265 ± 12 0.87 ± 680
        273 368 ± 8 368 ± 39 367 ± 20 367 ± 19
        275 131 ± 16 52.0 ± 1.5 130 ± 11 131 ± 10 131 ± 10 103 ± 3
Clearance (ml · min-1)
    Maternal
        267 55.0 ± 1.8 53.6 ± 1.1 54.8 ± 1.6 53.5 ± 1.0 53.5 ± 0.9 50 ± 34 50 ± 32 50 ± 32
        273 53.7 ± 2.9 51.0 ± 1.3 53.2 ± 2.1 51.0 ± 1.1 51.0 ± 0.9 55 ± 27 56 ± 22 56 ± 21
        275 50.1 ± 2.0 48.2 ± 0.7 49.9 ± 2.5 48.1 ± 2.3 48.1 ± 2.0 50 ± 16 48 ± 46 48 ± 44
    Fetala
        267 2.01 ± 0.02 2.01 ± 0.03 0.0003 ± 1.1 0.003 ± 0.36 0.12 ± 190
        273 2.31 ± 0.01 0.002 ± 1.6 0.005 ± 0.80
        275
1.17 ± 0.04
1.14 ± 0.003
0.0004 ± 1.3
0.0001 ± 1.1
1.07 ± 0.06
Fetal-to-maternal
Maternal-to-Fetal
Fetal/Maternal
P1M
P2M
P2MNFC
P1M
P2M
P2MNFC
P2MNFC
    Placental
        267 2.1 ± 1.1 2.07 ± 0.38 2.07 ± 0.03 1.78 ± 0.08 1.73 ± 0.05 1.73 ± 0.05 1.20 ± 0.04
        273 2.4 ± 1.6 2.39 ± 0.82 2.39 ± 0.03 1.93 ± 0.12 1.84 ± 0.06 1.84 ± 0.05 1.30 ± 0.04
        275
1.2 ± 1.3
1.19 ± 1.1
1.19 ± 0.02
0.92 ± 0.08
0.89 ± 0.07
0.89 ± 0.06
1.35 ± 0.10

  • ↵ a Corresponds to total fetal clearance for single analysis and direct (nonplacental) fetal clearance for paired analysis, respectively.