TABLE 5

Mean percentage of the dose of urinary and fecal metabolites of CP-544439 in SD rats and Beagle dogs following oral administration of [14C]CP-544439

The relative abundance of metabolites is based on the amount of radioactivity excreted in urine and feces.

Metabolite
Percentage of Dose: Rat
Percentage of Dose: Dog
Urine
Feces
Total
Urine
Feces
Total
CP-544439 8.3 29 37.3 1.5 95 96.5
M1 1.2 N.D. 1.2 3.2 N.D. 3.2
M2 6.6 19 25.6 0.48 N.D. 0.48
M3 5.3 3.9 9.2 0.67 N.D. 0.67
M4a Coeluted with M2 N.D. N.D. N.D.
M5 6.0 N.D. 6.0 0.43 N.D. 0.43
M6 4.6 2.2 6.8 0.4 N.D. 0.40
M7 N.D. 4.6 4.6 0.36 N.D. 0.36
M8b
N.D.
N.D.
N.D.
Coeluted with M3

  • N.D., not detected.

  • ↵ a Metabolite M4 coeluted with M2 but was a minor component of the peak (Fig. 2).

  • ↵ b Metabolite M8 coeluted with M3. The amount of M8 could not be assessed (Fig. 4).