TABLE 1

Permeation of pimecrolimus and tacrolimus after application to a 75-μm silicone elastomer membrane

Drug
Formulation
Fluxa
Silicone
Human Skinb
ng/cm2/h
Pimecrolimus 1% in propylene glycol/oleyl alcohol 9:1 748 ± 41 91 ± 9
Tacrolimus 1% in propylene glycol/oleyl alcohol 9:1 768 ± 66 816 ± 43
Pimecrolimus Elidel, 1% 131 ± 21 1.5 ± 0.8
Tacrolimus Protopic, 0.1% 15.5 ± 2.7 9.3 ± 1.6
Tacrolimus
Protopic, 0.03%
6.6 ± 1.7
6.6 ± 0.7

  • ↵ a Mean ± S.D. is given.

  • ↵ b Data from Billich et al. (2004) and Meingassner et al. (2005).