Drug | Formulation | Fluxa | ||
---|---|---|---|---|
Silicone | Human Skinb | |||
ng/cm2/h | ||||
Pimecrolimus | 1% in propylene glycol/oleyl alcohol 9:1 | 748 ± 41 | 91 ± 9 | |
Tacrolimus | 1% in propylene glycol/oleyl alcohol 9:1 | 768 ± 66 | 816 ± 43 | |
Pimecrolimus | Elidel, 1% | 131 ± 21 | 1.5 ± 0.8 | |
Tacrolimus | Protopic, 0.1% | 15.5 ± 2.7 | 9.3 ± 1.6 | |
Tacrolimus | Protopic, 0.03% | 6.6 ± 1.7 | 6.6 ± 0.7 |