Structural analogs of pactimibe and their metabolic stability in CYP2D6-expressing microsomes
Microsomal incubations were carried out at 37°C for up to 30 min. The final concentrations of CYP2D6 protein and substrates were set at 40 pmol/ml and 1 μM, respectively. The CYP2D6 stability of each compound is represented as the remaining percentage at 30 min compared with that at 0 min. Incubations were performed in duplicate.