EC50 values for CYP1A1/2 and CYP3A4
Inhibitor | CYP | Human Hepatocytes | NeoHep Cells | ||||
|---|---|---|---|---|---|---|---|
| R2 | EC50 | R2 | EC50 | ||||
| μM | μM | ||||||
| Nifedipine | 1A1/2 | 0.9965 | 213.2 ± 1.36 | 0.9838 | 106.3 ± 1.28 | ||
| 3A4 | 0.9960 | 87.22 ± 1.13 | 0.9986 | 51.23 ± 1.05 | |||
| Verapamil | 1A1/2 | 0.9893 | 92.60 ± 1.32 | 0.9999 | 54.73 ± 1.01 | ||
| 3A4 | 0.9969 | 149.0 ± 1.17 | 0.9994 | 87.20 ± 1.05 | |||
| Ketoconazole | 1A1/2 | 0.9971 | 28.14 ± 1.62 | 0.9947 | 15.16 ± 1.18 | ||
| 3A4 | 0.9683 | 6.039 ± 1.25 | 0.9995 | 3.954 ± 1.06 | |||
| Quercetin | 1A1/2 | 0.9974 | 171.2 ± 1.12 | 0.9977 | 84.04 ± 1.07 | ||
|
| 3A4 | 0.9954 | 62.33 ± 1.10 | 0.9999 | 41.86 ± 1.01 | ||