TABLE 1

Pharmacokinetic parameters after a 12-h radioactive intravenous infusion of 1.2 mg of rotigotine (data are pooled from all subjects)

	Total Radioactivity^b	Unconjugated Rotigotine	Rotigotine Sulfate	Rotigotine Glucuronide	N-Despropyl Rotigotine Sulfate	N-Desthienylethyl Rotigotine Sulfate and Other Conjugates
C_max (ng/ml)^a	4.160 (600)	0.509	1.479	0.410	0.621	0.287
T_max (h)	10.3 (1.5)	8	8	10	10	6
t_1/2 (h)	12.8 (5.8)	2.5	3.8	2.5	3.1	10.3
AUC_(0-t) (h · ng/ml)^a	65.37 (12.34)	5.972	17.381	3.360	6.908	3.985
AUC_(0-∞) (h · ng/ml)^a	69.72 (13.3)	6.126	17.696	3.428	7.146	n.c.^c
λ_z (1/h)	0.06 (0.02)	0.28	0.18	0.28	0.22	0.07
CL_r (L/h)^d	12.3		9.3	31.6	14.5
CL_f (L/h)^d	4.0

↵a ng, ng-equivalent.
↵b Mean (S.D.), per gram of plasma
↵c Not calculated (n.c.) because the extrapolated area beyond the last quantified sample would have exceeded 20% of the total AUC.
↵d Approximated by the quotient of mean amount excreted and AUC_(0-∞).