AUC0→∞ | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Gemfibrozil | E3040 | Troglitazone | Bisphenol A | 4-MU | ||||||
Gemfibrozil | Gem-G | E3040 | E3040G | Troglitazone | TGZ-G | Bisphenol A | Bis-AG | 4-MU | 4-MUG | |
nmol·min/ml | ||||||||||
Wild-type | 3330 ± 90 | 1500 ± 200 | 0.174 ± 0.030 | 11.7 ± 5.3 | 323 ± 60 | 246 ± 6 | N.D. | 620 ± 133 | N.D. | 2990 ± 600 |
Mrp3(−/−) | 3020 ± 140 | 431 ± 13** | 0.384 ± 0.110 | 0.500 ± 0.120** | 687 ± 181 | N.D. | N.D. | 61.7 ± 10.0** | N.D. | 753 ± 118** |
AUC, area under the plasma concentration-time curve; 4-MU, 4-methylumbelliferone; N.D., not detected.
↵** p < 0.01.