Day −7 | Day 1 | Day 3 | Day 4 | Day 9 | ||
---|---|---|---|---|---|---|
C max | (ng/ml) | 13 (0.30) | 79* (0.42) | 73* (0.56) | 80* (0.31) | 13 (0.13) |
T max | (h) | 1.5 (1.0, 3.0) | 1.0 (1.0, 2.0) | 2.0 (2.0, 3.0) | 2.0 (0.25, 2.0) | 1.5 (1.0, 3.0) |
CL/F | (ml/h/kg) | 28,820 (0.40) | 5082* (0.29) | 3092* (0.25) | 4091* (0.43) | 29,689 (0.26) |
AUC | (h · ng/ml) | 35 (0.40) | 197* (0.29) | 323* (0.25) | 244* (0.43) | 34 (0.26) |
Ratios to control (day −7) | ||||||
C max | 6.2 | 5.9 | 6.1 | 1.0 | ||
CL/F | 0.2 | 0.1 | 0.1 | 1.1 | ||
AUC | 6.0 | 9.9 | 7.3 | 1.0 |
↵* p < 0.001 compared with control values obtained on day −7.