Pharmacokinetic parameters of MDZ after oral administration (1 mg/kg) of MDZ in the absence and presence of AZM
Each value, with the exception of Tmax, represents the geometric mean (geometric coefficient of variation) of four monkeys. The Tmax values represent the median (minimum, maximum) of four monkeys.
| Day −7 | Day 1 | Day 3 | Day 4 | Day 9 | ||
|---|---|---|---|---|---|---|
| C max | (ng/ml) | 20 (0.31) | 38** (0.17) | 45** (0.22) | 31* (0.41) | 16 (0.19) |
| T max | (h) | 1.5 (1.0, 2.0) | 1.5 (0.5, 2.0) | 1.0 (0.5, 3.0) | 1.0 (0.5, 2.0) | 1.0 (1.0, 2.0) |
| CL/F | (ml/h/kg) | 19,512 (0.24) | 12,505 (0.37) | 10,641* (0.50) | 15,251 (0.54) | 26,953 (0.28) |
| AUC | (h · ng/ml) | 51 (0.24) | 80 (0.37) | 94* (0.50) | 66 (0.54) | 37 (0.28) |
| Ratios to control (day −7) | ||||||
| C max | 2.0 | 2.3 | 1.6 | 0.8 | ||
| CL/F | 0.7 | 0.6 | 0.8 | 1.4 | ||
| AUC | 1.6 | 2.0 | 1.4 | 0.7 |