TABLE 1

Human P450 genes responsible for xenobiotic metabolism, and their homologous mouse genes


Human P450 Gene Symbol

Mouse Homologous Gene Symbol

Mouse Gene ID

Mouse mRNA Accession Number

Mouse Protein Accession Number

Identity (%) of DNA

Identity (%) of Protein
CYP1A1 Cyp1a1 13076 NM 009992.3 NP 034122.1 82.7 80.6
CYP1A2 Cyp1a2 13077 NM 009993.3 NP 034123.1 79.9 73.0
CYP1B1 Cyp1b1 13078 NM 009994.1 NP 034124.1 81.8 81.0
CYP2A6 - - - -
CYP2A13 Cyp2a4 13086 NM 009997.2 NP 034127.2 84.3 86.6
CYP2B6 Cyp2b10 13088 NM 009999.3 NP 034129.1 78.1 75.8
CYP2C8 Cyp2c66 69888 NM 001011707.1 NP 001011707.1 78.4 72.4
CYP2C9 - - - -
CYP2C18 Cyp2c39 13098 NM 010003.1 NP 034133.1 79.1 74.2
CYP2C19 Cyp2c29 13095 NM 007815.3 NP 031841.3 79.8 74.7
CYP2D6 Cyp2d22 56448 NM 019823.3 NP 062797.3 79.9 75.8
CYP2E1 Cyp2e1 13106 NM 021282.2 NP 067257.1 79.4 78.1
CYP2F1 Cyp2f2 13107 NM 007817.2 NP 031843.2 82.6 81.9
CYP2J2 Cyp2j6 13110 NM 010008.4 NP 034138.3 78.3 76.2
CYP3A4 Cyp3a11 13112 NM 007818.3 NP 031844.1 78.1 72.8
CYP3A4 Cyp3a41b 53973 NM 017396.2 NP 059092.1 77.3 71.4
CYP3A5 Cyp3a13 13113 NM 007819.4 NP 031845.1 80.1 74.5
CYP3A7 Cyp3a16 13114 NM 007820.1 NP 031846.1 75.2 68.2
CYP3A43 Cyp3a25 56388 NM 019792.1 NP 062766.1 74.4 66.5
CYP4A11 Cyp4a10 13117 NM 010011.2 NP 034141.2 79.3 77.6
CYP4F3
Cyp4f18
72054
NM 024444.1
NP 077764.1
82.2
81.5
  • ID, identification.

    -, indicates no data in HomoloGene.