TABLE 1

Pharmacokinetic constants for plasma MDMA after administration of 2 and 10 mg/kg MDMA to rats

Parameters were calculated from MDMA time-concentration profiles depicted in Fig. 3, with WinNonlin noncompartmental modeling. Data are the mean ± S.D. for n = 4–5 rats/group.

MDMA Treatment	MDMA C_max	MDMA T_max	MDMA AUC	MDMA t_1/2
	ng/ml	h	h·ng/ml	h
2 mg/kg i.p.	210 ± 108	0.14 ± 0.08*	163 ± 56	0.80 ± 0.16
2 mg/kg s.c.	196 ± 50	0.75 ± 0.29	304 ± 65	0.79 ± 0.14
2 mg/kg p.o.	46 ± 15*	0.56 ± 0.31	61 ± 42*	0.77 ± 0.11
10 mg/kg i.p.	2257 ± 131^#	0.13 ± 0.04	3432 ± 278	1.08 ± 0.14
10 mg/kg s.c.	1130 ± 138	1.10 ± 0.22^#	3146 ± 514	1.27 ± 0.39
10 mg/kg p.o.	966 ± 49	0.31 ± 0.13	2226 ± 301^#	1.62 ± 0.41

↵* P < 0.05 compared with other routes at 2 mg/kg MDMA.
↵# P < 0.05 compared with other routes at 10 mg/kg MDMA.