TABLE 3

Pharmacokinetic constants for plasma MDA after administration of 2 and 10 mg/kg MDMA to rats

Parameters were calculated from MDA time-concentration profiles depicted in Fig. 5, with WinNonlin version 5.2. Data are the mean ± S.D. for n = 4–5 rats/group.

MDMA Treatment	MDA C_max	MDA T_max	MDA AUC	MDA t_1/2
	ng/ml	h	h·ng/ml	h
2 mg/kg i.p.	21 ± 13	0.75 ± 0.29	38 ± 20	2.51 ± 1.01
2 mg/kg s.c.	22 ± 12	2.00 ± 0.58*	73 ± 41	2.91 ± 1.23
2 mg/kg p.o.	13 ± 4	1.00 ± 0.54	24 ± 11	N.D.
10 mg/kg i.p.	201 ± 36	2.00 ± 0.71	987 ± 218	2.18 ± 0.48
10 mg/kg s.c.	145 ± 38	2.70 ± 0.45	685 ± 177	2.62 ± 1.17
10 mg/kg p.o.	132 ± 50	2.25 ± 0.50	727 ± 232	2.79 ± 1.22

N.D., not determined.
↵* P < 0.05 compared with other routes at 2 mg/kg.