Dose Recovered | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 Dose (5 mg/kg i.v.) | 1 Dose (0.5 mg/kg p.o.) | 1 Dose (5 mg/kg p.o.) | 1 Dose (50 mg/kg p.o.) | 5 Doses (5 mg/kg p.o.) | ||||||
Mean | S.D. | Mean | S.D. | Mean | S.D. | Mean | S.D. | Mean | S.D. | |
% | ||||||||||
Feces | 8.4 | 1.3 | 64.8 | 6.8 | 68.6 | 4.3 | 51.0 | 6.2 | 69.4 | 3.4 |
Urine | 86 | 12.5 | 38.0 | 8.6 | 28.6 | 1.6 | 37.2 | 10.0 | 22.3 | 1.4 |
Tissues | 0.1 | 0.1 | N.D. | N.D. | N.D. | N.D. | 0.3 | 0.6 | 0.9 | 0.3 |
Total recovery | 92.2 | 11.4 | 102.8 | 7.6 | 97.2 | 5.2 | 88.5 | 10.8 | 92.7 | 4.4 |
N.D., not determined.
↵a Studies were terminated 72 h after administration.
b Studies were terminated 24 h after final administration.