Dose | AUC0–∞ | t1/2α | t1/2β | CLf | Vss | Cmax | Tmax | F | |
---|---|---|---|---|---|---|---|---|---|
μg | min·μg/ml | min | h | ml/min | ml | μg/ml | min | % | |
Intravenous | 907 | 274 | 33.3 | 6.8 | 3.3 | 1495 | —a | — | — |
Oral | 8157 | 1069 | 20.9 | 5.6 | 7.6 | — | 1.8 | 89.1 | 43.4 |
AUC0–∞, area under the blood concentration-time curve from 0 to infinity; t1/2α, distribution half-life; t1/2β, terminal elimination half-life; CLf, total final systemic clearance from blood; Vss, volume of distribution at steady-state; Cmax, maximum concentration of analyte in blood; Tmax, time to maximal concentration; F, systemic bioavailability of BmPy-Cl.
↵a —, data not predicted by pharmacokinetic models.