TABLE 3

ADME genes that responded differently to inducers between nontumor- and tumor-bearing athymic nude mice

The -fold change was obtained from the signal in the treated sample divided by the mean value of the corresponding control (vehicle), for example, MC treatment in tumor-bearing mice vs. control (vehicle) in tumor-bearing mice and MC treatment in nontumor-bearing mice vs. control (vehicle) in nontumor-bearing mice. The statistical difference of -fold changes between tumor-bearing and nontumor-bearing mice in each treatment was determined by a t test using treatment comparison in Spotfire. ″P″ and ″M″ in the Flag column indicate ″present″ and ″marginal,″ respectively, as described under Materials and Methods.