Peff and fabs for R- and S-VER together with other perfusion parameters for the group that was administered racemic VER alone (T1) and for the group that received racemic VER together with ketoconazole (T2)
T1: 1200 mg/l, total dose 240 mg; n = 4. T2: verapamil: 1200 mg/l, total dose 240 mg; ketoconazole: 33 mg/l, total dose 8 mg; n = 3. Values are presented as mean and S.D.
| T1 | T2 | p: T1 vs. T2 | |
|---|---|---|---|
| R-VER | |||
| Peff (10−4 cm/s) | 0.97 ± 0.50 | 1.64 ± 0.57 | 0.16 |
| fabs (%) | 19 ± 9 | 26 ± 8 | 0.31 |
| S-VER | |||
| Peff (10−4 cm/s) | 1.15 ± 0.98 | 1.49 ± 0.37 | 0.59 |
| fabs (%) | 21 ± 15 | 25 ± 6 | 0.62 |
| PEG 4000 recovery (%) | 90 ± 9 | 90 ± 3 | 0.98 |
| NWF (ml/h/cm) | 1.8 ± 1.6 | 0.7 ± 0.7 | 0.35 |
| Qout (ml/min) | 2.0 ± 0.3 | 1.9 ± 0.1 | 0.44 |
| pH | 6.53 ± 0.03 | 6.56 ± 0.06 | 0.069 |
| Osmolality (mOsmol/kg) | 287 ± 19 | 285 ± 25 | 0.82 |